Research

Enzyme and Biosensor Engineering

Harnessing the power of proteins: Our lab pushes the boundaries of protein engineering, combining three different strategies: rational design, directed evolution, and machine learning. This allows us to create customized enzymes and biosensors with tailored properties for diverse applications. Imagine enzymes engineered to specifically and quickly degrade plastic waste or biosensors capable of detecting a wide range of compounds with high accuracy and sensitivity.

Representative paper:
Nearmnala et al. (2021) An in vivo selection system with tightly regulated gene expression enables directed evolution of highly efficient enzymes. Scientific Reports.
http://www.nature.com/articles/s41598-021-91204-4

Molecular Toolkits for Synthetic Biology

Building biological Legos: We design and optimize genetic parts, the fundamental building blocks of synthetic biology. Imagine these as programmable Legos that, when assembled, orchestrate intricate biological functions within living cells. Our focus lies in equipping these parts with user-defined functionalities, enabling the construction of sophisticated biological circuits for specific goals like producing valuable biochemicals or even creating live therapeutics.

Microbial Cell Factories and Biocatalysis

Nature's Tiny Powerhouses: We transform microbes into efficient cell factories, harnessing their metabolic machinery for specific industrial and agricultural applications. Think of them as tiny, green factories producing sustainable products or biocatalysts that perform specific chemical reactions with remarkable efficiency and eco-friendliness. Our aim is to design and optimize these microbial powerhouses for a greener and more sustainable future.